MicroRNA-192* impairs adipocyte triglyceride storage
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- 作者：Raghavendra Mysorea ; You Zhoua ; Sanja Sä ; devirtaa ; b ; Hanna Savolainen-Peltonenc ; d ; P.A. Nidhina Haridasa ; Jarkko Soronena ; e ; Marja Leivonenf ; Antti-Pekka Sarine ; g ; Pamela Fischer-Posovszkyh ; Martin Wabitschh ; Hannele Yki-Jä ; rvinena ; b ; Vesa M. Olkkonena ; i ; vesa.olkkonen@helsinki.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALDH3A2 ; aldehyde dehydrogenase 3 family member A2 ; aP2 ; adipocyte protein 2 ; BMI ; body mass index ; GLUT4 ; glucose transporter type 4 ; miRNA ; microRNA ; NT ; non-targeting ; PLIN ; perilipin 1 ; qPCR ; quantitative reverse transcriptase PCR ; SCARB1 ; scavenger receptor B ; type I ; SCD ; stearoyl coenzyme A desaturase-1 ; SGBS ; Simpson&ndash ; Golabi&ndash ; Behmel syndrome ; TG ; triglyceride ; VAT ; visceral adipose tissue
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1861
- 期：4
- 页码：342-351
- 全文大小：1141 K
文摘
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Visceral adipose tissue (VAT) miR-192* correlates negatively with serum TG and positively with HDL in morbidly obese subjects.
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VAT miR-192* correlates negatively with BMI in a less obese/overweight patient cohort.
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miR-192* overexpression impairs adipocyte triglyceride storage.
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miR-192* overexpression reduces the mRNA and protein levels of key adipogenic genes.
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SCD and ALDH3A2 are direct targets of miR-192*.