Antiviral action of the antimicrobial peptide ALFPm3 from Penaeus monodon against white spot syndrome virus

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• 作者：Thanachai Methatham¹ ; Pakpoom Boonchuen¹ ; Phattarunda Jaree ; Anchalee Tassanakajon ; Kunlaya Somboonwiwat ; ^{kunlaya.s@chula.ac.th}
• 关键词：ALFPm3 ; WSSV ; Penaeus monodon ; Antiviral activity ; Host-viral interaction
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：69
• 期：Complete
• 页码：23-32
• 全文大小：2733 K
• 卷排序：69

文摘

The interactions between ALFPm3 and its interacting proteins, WSSV186, WSSV395, WSSV458, and WSSV471 were confirmed. WSSV186 and WSSV471 proteins are structural proteins located on WSSV-nucleocapsid and -envelope, respectively. All ALFPm3-interacting proteins could interfere with the WSSV-neutralizing activity of rALFPm3. The ALFPm3 performed its anti-WSSV action by binding to the target structural proteins complex leading to WSSV virion damage.