Ultrasound and magnetic resonance imaging assessment of joint disease in symptomatic patients with cystic fibrosis arthropathy

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• 作者：G. Fitch^a ; K. Williams^a ; J.E. Freeston^b ; ^d ; S. Dass^b ; A. Grainger^c ; ^d ; R. Hodgson^d ; L. Horton^d ; P. Whitaker^a ; D. Peckham^a ;
• 关键词：Cystic fibrosis ; Arthropathy ; Ultrasound ; MRI ; Joint count
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：15
• 期：4
• 页码：e35-e40
• 全文大小：200 K

文摘

Cystic fibrosis arthropathy (CFA) is a term commonly used for joint pain with and without swelling seen in some patients with CF. Early studies into CFA focused on the presence of rheumatoid factor and immunological changes on synovial biopsy, with parallels drawn between respiratory and joint activity. Identification of anti-cyclic citrullinated peptide antibodies (anti-CCP) as a marker of rheumatoid arthritis (RA), along with increased access to sensitive imaging techniques including ultrasound (US) and magnetic resonance imaging (MRI), offer great potential to investigate and more accurately understand the type(s) of inflammatory arthritis that may underlie CFA. The aim of this study was to phenotype an active CFA cohort using serology and imaging, as a basis for further work in this understudied area.

Methods

This was a prospective observational cohort study of symptomatic CFA patients presenting with joint pain. Participants underwent serological testing, clinical and US joint and entheseal assessment, as well as MRI of the most symptomatic joint/joint area.

Results

Ten symptomatic patients were studied with 9/10 having positive clinical findings. Inflammatory changes on US were seen in 8/10 cases. Five patients had positive findings on MRI (3 of whom had received IV gadolinium contrast). This included patients with significant erosive changes. One patient was anti-CCP positive suggestive of RA, and two were anti-nuclear antibody positive.

Conclusion

Imaging, and to a lesser extent serology, identified inflammatory joint pathology in a proportion of cases, providing important data to explore in a large CFA cohort examining the clinical and imaging phenotype of this group.