Design, synthesis and evaluation of a new Mn - Contrast agent for MR imaging of myocardium based on the DTPA-phenylpentadecanoic acid complex
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- 作者：Maxim L. Belyanina ; Elena V. Stepanovaa ; eline_m@mail.ru" class="auth_mail" title="E-mail the corresponding author ; glycoside.m@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Rashid R. Valievb ; c ; d ; Victor D. Filimonova ; Vladimir Y. Usove ; Oleg Y. Borodine ; f ; g ; Hans Å ; grend
- 关键词：MRI-contrast agent ; DFT ; Molecular docking ; Manganese ; Gadolinium
- 刊名：Chemical Physics Letters
- 出版年：2016
- 出版时间：16 November 2016
- 年：2016
- 卷：665
- 期：Complete
- 页码：111-116
- 全文大小：1419 K
文摘
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New contrast agent for heart MRI (DTPA-PPDA Mn (II)) was designed and synthesized for the first time.
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Phantom experiments revealed good degree of amplification of T1-weighted images.
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DFT calculations showed higher complexation constant than for DTPA Mn (II).
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Molecular docking revealed high affinity to a heart-type fatty acid binding protein.