Nemo-like kinase 1 (Nlk1) and paraxial protocadherin (PAPC) cooperatively control Xenopus gastrulation through regulation of Wnt/planar cell polarity (PCP) signaling

详细信息    查看全文

• 作者：Rahul Kumar ; Anja Ciprianidis ; Susanne Thei&szlig ; Herbert Steinbei&szlig ; er ; Lilian T. Kaufmann ; ^{lilian.kaufmann@med.uni-heidelberg.de}
• 关键词：PCP ; planar cell polarity ; CE ; convergent extension ; AC ; animal cap ; MO ; morpholino oligonucleotide ; IP ; immunoprecipitation ; IF ; immunofluorescence
• 刊名：Differentiation
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：93
• 期：Complete
• 页码：27-38
• 全文大小：2078 K
• 卷排序：93

文摘

Nlk1 regulates Xenopus gastrulation via PAPC-dependent Wnt/PCP control. Direct interaction of Nlk1 with PAPC stabilizes both proteins. The kinase activity of Nlk1 is not essential for the regulation of PAPC. Conserved serine residues in the PAPC C-terminus control its stability and function.