Synthesis of novel anticancer ruthenium-arene pyridinylmethylene scaffolds via three-component reaction

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• 作者：Gajanan Raosaheb Jadhav^&dagger ; ; Sohini Sinha^&dagger ; ; Mohit Chhabra ; Priyankar Paira ; ^{priyankar.paira@vit.ac.in" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ruthenium dimer ; Ruthenium&ndash ; arene pyridinylmethylene scaffolds ; Three component reactions ; Anticancer activity ; Fluorescence profile ; Toxicity study
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 June 2016
• 年：2016
• 卷：26
• 期：11
• 页码：2695-2700
• 全文大小：660 K

文摘

A novel three components approach for the synthesis of bioactive Ru–arene pyridinylmethylene complexes has been developed using pyridine carboxaldehyde, amino pyridine and dichloro (p-cymene) ruthenium(II) dimer as starting materials. These scaffolds were screened for their anticancer activity against breast cancer (MCF7) and human Epitheloid Cervix Carcinoma (HeLa) cell line. It was established that compounds [(η⁶-pcymene)RuCl(κ²-N,N-(3,5-dinitro-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF₆ (4o), [(η⁶-pcymene)RuCl(κ²-N,N-N-(3,5-dibromo-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF₆ (4c), [(η⁶-pcymene)RuCl(κ²-N,N-(3,5-dibromo-6-methylpyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF₆ (4j) and [(η⁶-pcymene)RuCl(κ²-N,N-3(3-bromo-5-methyl-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF₆ (4b) were significantly active against both the cell lines.