Simple sequence repeat variations expedite phage divergence: Mechanisms of indels and gene mutations
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- 作者：Tiao-Yin Lin ; tylin@cc.nctu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：SSR ; simple sequence repeat ; NRUBME ; non-repeat-unit-based misalignment-elongation ; T7M ; T7 Meselson ; DTRs ; direct terminal repeats ; RA ; relative abundance ; RD ; relative density ; RCRs ; recombinant regions ; NRCRs ; non-recombinant regions ; nWC ; non-Watson-Crick ; PDH ; pyruvate dehydrogenase ; XP ; xeroderma pigmentosum
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：789
- 期：Complete
- 页码：48-56
- 全文大小：1959 K
文摘
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SSR variations account for over half of the genomic changes between T7M and T3.
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Mutations of SSRs are categorized into four classes of events.
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Mechanisms of nucleotide indels without preexisting repeat sequence are proposed.
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The first evidence of SSR variations accelerating phage genetic divergence is shown.
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The mechanism for initiation of human di- to tetranucleotide repeat is explained.