Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes
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- 作者：Lingwen Konga ; b ; 1 ; jcdong2004@126.com" class="auth_mail" title="E-mail the corresponding author ; Jiaqi Liua ; b ; 1 ; Jia Wangc ; Qingli Luoa ; b ; Hongying Zhanga ; b ; Baojun Liua ; b ; Fei Xua ; b ; Qi Pangd ; Yingchao Liud ; Jingcheng Donga ; b ;
- 关键词：Inflammation ; Icariin ; Cytokines ; P38MAPK ; Substance P
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：401-407
- 全文大小：970 K
文摘
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ICA inhibited TNF-α/IFN-γ induced inflammatory mediators in HaCaT cells.
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ICA suppressed IL-6,IL-8, IL-1β and ICAM-1 mRNA expression.
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ICA down-regulated the expression of TACR1 and inactivated p38 MAPK pathways.
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ICA regulated TNF-α-R1 and IFN-γ-R1 expression in HaCaT cells.