ICA inhibited TNF-α/IFN-γ induced inflammatory mediators in HaCaT cells.
ICA suppressed IL-6,IL-8, IL-1β and ICAM-1 mRNA expression.
ICA down-regulated the expression of TACR1 and inactivated p38 MAPK pathways.
ICA regulated TNF-α-R1 and IFN-γ-R1 expression in HaCaT cells.