Tadalafil reduces airway hyperactivity and protects against lung and respiratory airways dysfunction in a rat model of silicosis
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- 作者：Rania R. Abdelaziza ; Wagdi F. Elkashefb ; Eman Saida ; emansaid@mans.edu.eg" class="auth_mail" title="E-mail the corresponding author ; eman-sa3eed@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silicosis ; TGFβ1 ; TNFα ; Airway hyperactivity ; Tadalafil ; Phosphodiesterase-5
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：530-541
- 全文大小：3141 K
文摘
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Tadalafil ameliorates pulmonary silicosis.
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Tadalafil reduces TGFβ1 and TNFα expression.
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Tadalafil enhances blood flow to hypoxic tissue.
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Tadalafil improves oxidants/antioxidants balance.
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Tadalafil decreases airways hyperactivity.