Multiple molecular forms of glucagon and insulin in the kaluga sturgeon, Huso dauricus

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• 作者：Andoh ; Tadashi ; Nagasawa ; Hiromichi ; Matsubara ; Takahiro
• 关键词：Kaluga sturgeon ; Huso dauricus ; Chondrostei ; Insulin ; Glucagon ; Amino acid sequence ; Primary structure ; Tetraploidy ; Gene amplification
• 刊名：Peptides
• 出版年：2000
• 出版时间：December, 2000
• 年：2000
• 卷：21
• 期：12
• 页码：1785-1792
• 全文大小：384 K

文摘

Five molecular forms of glucagon and two molecular forms of insulin were characterized from the kaluga sturgeon. Substitutions occurred at two to thirteen internal amino acid residues among the five molecular forms of glucagons, indicating that these glucagons were encoded by five distinct genes. The amino acid sequences of two insulins from the kaluga sturgeon were identical to those of paddlefish insulin-II and Russian sturgeon insulin except that kaluga sturgeon insulin-I had an extension of five residues at the B-chain N-terminus. This is the first demonstration that more than two molecular forms of glucagon have been characterized from a single animal species.