In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium

详细信息    查看全文

• 作者：Toshi Nagata ; Taiki Aoshi ; Masato Uchijima ; Yukio Koide
• 关键词：DNA immunization ; Th epitope ; Listeria monocytogenes
• 刊名：Vaccine
• 出版年：2008
• 出版时间：19 September 2008
• 年：2008
• 卷：26
• 期：40
• 页码：5123-5127
• 全文大小：299 K

文摘

Cellular immunity is indispensable for efficient protection against intracellular bacterial infection. CD4⁺ and CD8⁺ T cells specific for a variety of antigenic peptides derived from particular bacteria are induced after the infection. T cells recognizing different antigenic peptides have been speculated to have different functions in terms of the protective immunity. We here induced individual CD4⁺ T cells specific for each antigenic peptide derived from Listeria monocytogenes independently with DNA vaccines using gene gun bombardment and compared the CD4⁺ T-cell populations for their ability on the specific protective immunity against lethal listerial challenge and analyzed their characteristics.