Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury
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- 作者：Masahiro Nagahama ; nagahama@ph.bunri-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Soshi Seike ; Hidenori Shirai ; Teruhisa Takagishi ; Keiko Kobayashi ; Masaya Takehara ; Jun Sakurai
- 关键词：C. perfringens beta-toxin ; P2X7 receptor ; Pore-forming toxin ; Oligomer formation
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1850
- 期：11
- 页码：2159-2167
- 全文大小：804 K
文摘
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We demonstrate that P2X7 receptor is a target molecule of beta-toxin.
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Beta-toxin-induced lethality in mouse is blocked by P2X7 receptor antagonist.
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P2X7 receptor is a new therapeutic target for the treatment of C. perfringens type C infection.