Comparison of the Virucidal Effects of Disinfectant Agents Against Equine Influenza A Virus

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• 作者：Takashi Yamanaka ; DVM ; PhD ; ^{tyamanaka19951127@gmail.com" class="auth_mail} ; Hiroshi Bannai ; DVM ; PhD ; Koji Tsujimura ; DVM ; PhD ; Manabu Nemoto ; DVM ; PhD ; Takashi Kondo ; DVM ; PhD ; Tomio Matsumura ; DVM ; PhD
• 关键词：Biosecurity measure ; Disinfectant ; Equine influenza A virus ; H3N8
• 刊名：Journal of Equine Veterinary Science
• 出版年：May 2014
• 年：2014
• 卷：34
• 期：5
• 页码：715-718
• 全文大小：185 K

文摘

Disinfection is one of the most important biosecurity measures to minimize disease spread during outbreaks of equine influenza. Although many disinfectants are commercially available, information about their effects against equine influenza A virus (EIV) is limited. This report describes an evaluation of the effects of six disinfectants against EIV (∼10^4.7 egg infectious dose 50/200 渭L) under different conditions (reaction time [10 and/or 30 minutes], temperature [4°C–25°C], and the absence and/or presence of uninfected allantoic fluid that served as our best choice of “organic matter” equivalent). Although the efficacy of didecyldimethylammonium chloride decreased with decreasing reaction temperature, the compound showed the highest efficacy of the three quaternary ammonium compounds tested in this study. The effects of sodium dichloroisocyanurate and nonoxynol iodine were not affected by reaction time or temperature, but they were affected by the presence of organic matter. Antec Virkon S containing potassium peroxymonosulfate and sodium chloride consistently inactivated EIV regardless of reaction time, temperature, and the presence of organic matter. These findings will help us to take rational biosecurity measures during outbreaks of equine influenza.