Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo
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- 作者：Taku Nagai1 ; 10 ; 11 ; Shinichi Nakamuta2 ; 10 ; 11 ; Keisuke Kuroda2 ; 10 ; 11 ; Sakura Nakauchi2 ; 10 ; Tomoki Nishioka2 ; 10 ; Tetsuya Takano2 ; 10 ; Xinjian Zhang2 ; Daisuke Tsuboi2 ; 10 ; Yasuhiro Funahashi2 ; 10 ; Takashi Nakano3 ; 10 ; Junichiro Yoshimoto4 ; 10 ; Kenta Kobayashi5 ; Motokazu Uchigashima6 ; Masahiko Watanabe6 ; Masami Miura7 ; Akinori Nishi8 ; 10 ; Kazuto Kobayashi9 ; Kiyofumi Yamada1 ; 10 ; Mutsuki Amano2 ; 10 ; 11 ; Kozo Kaibuchi2 ; 10 ; kaibuchi@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：3 February 2016
- 年：2016
- 卷：89
- 期：3
- 页码：550-565
- 全文大小：5569 K
文摘
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Phosphoproteomic analysis identified PKA substrates downstream of D1R
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More than 100 candidate substrates of PKA were found, including Rap1 GEF (Rasgrp2)
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PKA-mediated Rasgrp2 phosphorylation enhances its GEF activity on Rap1
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Rap1 activation regulates neuronal excitability and cocaine reward-related behavior