Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa
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- 作者：Hisashi Matsuda ; Kazutoshi Yoshida ; Katsutoshi Miyagawa ; Yasunobu Asao ; Saya Takayama ; Souichi Nakashima ; Fengming Xu ; Masayuki Yoshikawa
- 关键词：Rotenoids ; Anti-invasion ; Anti-proliferation ; Differentiation-inducing activity ; HT1080 ; U937 ; HL-60
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2007
- 出版时间：1 February 2007
- 年：2007
- 卷：15
- 期：3
- 页码：1539-1546
- 全文大小：260 K
文摘
Principal rotenoids (deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3–30 μM) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti-proliferative activities.