Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with KitWv Mutations
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- 作者：Ayano Yurino1 ; Katsuto Takenaka2 ; Takuji Yamauchi1 ; Takuya Nunomura1 ; Yasufumi Uehara1 ; Fumiaki Jinnouchi1 ; Kohta Miyawaki1 ; Yoshikane Kikushige1 ; Koji Kato1 ; Toshihiro Miyamoto1 ; Hiromi Iwasaki2 ; Yuya Kunisaki2 ; Koichi Akashi1 ; 2 ; akashi@med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：7
- 期：3
- 页码：425-438
- 全文大小：3503 K
文摘
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KitWv mutations in mice (BRGSKWv/Wv) promote human multi-lineage reconstitution
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Robust human erythropoiesis and thrombopoiesis are reconstituted in BRGSKWv/Wv
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Exogenous human cytokine is not required for multi-lineage engraftment in BRGSKWv/Wv
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KitWv mutations allow human HSPCs to outcompete mouse HSPCs in bone marrow niches