Structure–activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S₃ cells

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• 作者：Akiyuki Ikedo ; Ichiro Hayakawa ; Takeo Usui ; Sayaka Kazami ; Hiroyuki Osada ; Hideo Kigoshi
• 关键词：ructure– ; activity relationship study ; Glaziovianin A ; Isoflavone ; Antitumor activity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：15 September 2010
• 年：2010
• 卷：20
• 期：18
• 页码：5402-5404
• 全文大小：487 K

文摘

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S₃ cells was investigated. Compared to glaziovianin A, the O⁷-allyl derivative was found to be more cytotoxic against HeLa S₃ cells and a more potent M-phase inhibitor.