Convenient green preparation of dipeptides using unprotected α-amino acids

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• 作者：Tetsuya Ezawa ; Seunghee Jung ; Yuya Kawashima ; Takuya Noguchi ; Nobuyuki Imai ; ^{nimai@cis.ac.jp}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：75-83
• 全文大小：2396 K
• 卷排序：28

文摘

Dipeptides and amides were obtained in high yields from N-carbobenzyloxy α-amino acids and 3-phenylpropanoic acid with unprotected α-amino acids via the corresponding mixed carbonic carboxylic anhydrides using ethyl chloroformate and triethylamine by an ecological and convenient method in which the protection of C-terminals is not needed.