Dynamic control of the mevalonate pathway expression for improved zeaxanthin production in Escherichia coli and comparative proteome analysis
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- 作者：Hong-Jie Shen ; Bi-Yan Cheng ; Yan-Mei Zhang ; Liang Tang ; Zhen Li ; Yi-Fan Bu ; Xi-Ran Li ; Gui-Qiao Tian ; Jian-Zhong Liu ; lssljz@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zeaxanthin (PubChem CID ; 5280899)
- 刊名：Metabolic Engineering
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：180-190
- 全文大小：1774 K
文摘
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Dynamic control of the TIGR-mediated MEV pathway by IPP/FPP-responsive promoter.
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722.46 mg/L and 23.16 mg/g DCW of zeaxanthin was produced in 5.0 L fed-batch fermentation.
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The strain achieved the highest level of zeaxanthin ever reported.
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The mechanism of zeaxanthin overproduction was obtained by proteome analysis.
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Zeaxanthin production may be related to oxidative stress and cellular shape change.