Global gene expression profiling of human bronchial epithelial cells exposed to airborne fine particulate matter collected from Wuhan, China
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- 作者：Xiaojie Dinga ; b ; Meilin Wanga ; b ; Haiyan Chua ; b ; Minjie Chuc ; Tong Naa ; Yang Wenc ; Dongmei Wua ; b ; Bin Hand ; Zhipeng Baid ; Weihong Chene ; Jing Yuane ; Tangchun Wue ; Zhibin Huc ; Zhengdong Zhanga ; b ; drzdzhang@gmail.com" class="auth_mail ; Hongbing Shenc ; hbshen@njmu.edu.cn" class="auth_mail
- 关键词：PM2.5 ; Gene expression ; Oxidative stress ; Cell viability ; Cell cycle
- 刊名：Toxicology Letters
- 出版年：3 July 2014
- 年：2014
- 卷：228
- 期：1
- 页码：25-33
- 全文大小：1084 K
文摘
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This is the first transcriptomic study in China evaluating the use of microarray technology to elucidate the cellular response to PM2.5.
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We observed that different concentrations of PM2.5 had a distinct effect on the gene expression in HBE cells.
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We identified many genes and pathways that altered significantly in HBE cells after PM2.5 exposures.