Reproductive factors in relation to ovarian cancer: a case-control study in Northern Vietnam

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• 作者：Duc-Cuong Le ; Tatsuhiko Kubo ; Yoshihisa Fujino ; David C. Sokal ; Trinh Huu Vach ; Truong-Minh Pham ; Shinya Matsuda
• 关键词：Reproductive factors ; Ovarian cancer ; Vietnamese women ; Northern Vietnam ; Vietnam
• 刊名：Contraception
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：86
• 期：5
• 页码：494-499
• 全文大小：135 K

文摘

Background

Ovarian cancer, one of the most common cancers in women and the most serious gynecologic cancer, is known to be influenced by reproductive factors, but these factors have not previously been examined in Vietnamese women.

Study Design

We analyzed 262 ovarian cancer patients recruited from 27 hospitals in 12 provinces and Ha Noi City from April 2001 to May 2006, plus 755 controls matched by age and residential address.

Results

The risk of ovarian cancer was significantly lower in parous women than nulliparous women. Use of an intrauterine contraceptive device was also associated with a reduced risk. In contrast, induced abortion, late menopause and years of ovulation were significantly associated with an increased risk of cancer.

Conclusions

Parity and intrauterine device use were associated with a reduced risk of ovarian cancer in Vietnamese women, whereas induced abortion, late menopause and years of ovulation were associated with an increased risk.