Synthesis of 3,3-dimethyl-2-phenyl-3H-pyrrole from Isopropyl Phenyl Ketoxime and Acetylene: A Side Formation of 4,4-dimethyl-5-phenyl-1-vinyl-2-pyrrolidinone as Clue to the Reaction Mechanism

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• 作者：Dmitrii A. Shabalin ; Tatyana E. Glotova ; Elena Yu. Schmidt ; Igor A. Ushakov ; Al&rsquo ; bina I. Mikhaleva ; Boris A. Trofimov ; ^{boris_trofimov@irioch.irk.ru" class="auth_mail}
• 刊名：Mendeleev Communications
• 出版年：March-April, 2014
• 年：2014
• 卷：24
• 期：2
• 页码：100-101
• 全文大小：245 K

文摘

Isopropyl phenyl ketoxime reacts with acetylene in the KOH/DMSO suspension (atmospheric pressure, 90 掳C, 4 h) to afford 3,3-dimethyl-2-phenyl-3H-pyrrole (30%) and 4,4-dimethyl-5-phenyl-1-vinyl-2-pyrrolidinone (5%) that is likely originated from 4,4-dimethyl-5-phenyl-3,4-dihydro-2H-pyrrol-2-ol as the key reaction intermediate.