Preparation of respirable nanoparticle agglomerates of the low melting and ductile drug ibuprofen: Impact of formulation parameters

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• 作者：Maria Malamatari^a ; ^{maria.malamatari.12@ucl.ac.uk}Author Vitae ; Satyanarayana Somavarapu^aAuthor Vitae ; Kyriakos Kachrimanis^bAuthor Vitae ; Graham Buckton^aAuthor Vitae ; Kevin M.G. Taylor^a ; ^{kevin.taylor@ucl.ac.uk}Author Vitae
• 关键词：Dry powder inhaler ; Full factorial design ; Ibuprofen ; Nanocrystal ; Spray drying ; Wet milling
• 刊名：Powder Technology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：308
• 期：Complete
• 页码：123-134
• 全文大小：2001 K
• 卷排序：308

文摘

Respirable nanoparticle agglomerates of ibuprofen were produced by wet milling and spray drying. The impact of formulation factors on the yield and performance of the powders was studied using a 23 full factorial design. The nanoparticle agglomerates were crystalline and exhibited enhanced dissolution profiles. The stabilizer used for the formation of the nanosuspensions can affect the yield and size of nanoparticle agglomerates. Mannitol and leucine are useful excipients for the spray drying of nanosuspensions to produce respirable particles.