Transition metal-free Minisci reaction promoted by NCS, and TBHP: acylation of heteroarenes

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• 作者：Yogesh Siddaraju ; Kandikere Ramaiah Prabhu ; ^{prabhu@orgchem.iisc.ernet.in" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Isoquinoline ; Minisci reaction ; C&ndash ; H functionalization ; Acylation ; Metal-free reactions
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：18 February 2016
• 年：2016
• 卷：72
• 期：7
• 页码：959-967
• 全文大小：984 K

文摘

A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant. This method has been successfully employed in acylation of a variety of aldehyde with heteroarenes. The application of the method has been illustrated in synthesizing isoquinoline derived natural products. This strategy provides an efficient, mild and inexpensive method for acylation of heteroarenes.