Phosphoproteome analysis revealed the upregulation of NDPK2 phosphorylation following exogenous Tub>3ub> injection.
NDPK2 was prerequisite for the opening and reopening of the sensitive period downstream of Tub>3ub> action.
NDPK2 participated in the memory priming process by Tub>3ub> signaling which endowed the potential for learning.