Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks
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- 作者：Colin Sopera ; 1 ; Evan Wickera ; 1 ; Catherine V. Kulicka ; Prosper N&rsquo ; Gouemob ; c ; Patrick A. Forcellia ; b ; Paf22@georgetown.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Absence epilepsy ; Temporal lobe epilepsy ; Generalized epilepsy ; Rat ; Channelrhodopsin-2 ; Partial seizure ; Deep brain stimulation
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：102-115
- 全文大小：2260 K
文摘
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Optogenetic activation of DLSC suppressed seizures evoked by pentylenetetrazole
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Optogenetic activation of DLSC suppressed Area Tempestas-evoked forebrain seizures
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Optogenetic activation of DLSC suppressed thalamocortical seizures
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Optogenetic activation of DLSC suppressed brainstem seizures in a genetic rat model
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Seizure suppression was effective at frequencies as low as 5 Hz