Repair of rotator cuff injuries using different composites

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• 作者：Y. Lopiz^a ; ^{yaizalopiz@gmail.com} ; C. Arvinius^a ; C. Garcí ; a-Ferná ; ndez^a ; M.C. Rodriguez-Bobada^b ; P. Gonzá ; lez-Ló ; pez^b ; A. Civantos^c ; F. Marco^a
• 关键词：Bone morphogenetic protein ; Repair ; Rotator cuff ; Biomaterials ; Tissue engineering
• 刊名：Revista Española de Cirugía Ortopédica y Traumatología (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：61
• 期：1
• 页码：51-62
• 全文大小：3161 K
• 卷排序：61

文摘

Rotator cuff repairs have shown a high level of re-ruptures. It is hypothesised that the use of rhBMP-2 in a carrier could improve the biomechanical and histological properties of the repair.Material and methodsControlled experimental study conducted on 40 rats with section and repair of the supraspinatus tendon and randomisation to one of five groups: Group 1 (control) only suture; Group 2 (double control), suture and alginate-chitin carrier; Group 3 (alginate-control), the rhBMP-2 was added to the alginate; Group 4 (chitin-control), application of the rhBMP-2 to the chitin; and Group 5 (double sample): the two components of the carrier (alginate and chitin) have rhBMP-2. A biomechanical and histological analysis was performed at 4 weeks.ResultsA gap was observed in all cases 4 weeks after supraspinatus detachment. The re-rupture rate was 7.5%, with 20% of them in the control-alginate group. Histologically the best results were obtained in the double sample group: 4.5 (3.3–5.0). Double sample were also able to support higher loads to failure: 62.9 N (59.8–69.4) with lower rigidity 12.7 (9.7–15.9).ConclusionsThe use of alginate-chitin carrier with rhBMP-2 improves the biomechanical and histological properties of the repair site in a chronic rotator cuff tear.