Two-year follow-up data from the STEPP-AMI study: A prospective, observational, multicenter study comparing tenecteplase-facilitated PCI versus primary PCI in Indian patients with STEMI

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• 作者：Suma M. Victor^a ; ^{sumavictor@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; S. Vijayakumar^b ; Thomas Alexander^c ; C.G. Bahuleyan^d ; Arun Srinivas^e ; S. Selvamani^f ; S. Marutha Priya^g ; K. Kamaleswari^h ; Ajit S. Mullasari^b ; ⁱ
• 关键词：ST elevation myocardial infarction ; Timely reperfusion ; Pharmacoinvasive strategy
• 刊名：Indian Heart Journal
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：68
• 期：2
• 页码：169-173
• 全文大小：454 K

文摘

A pharmacoinvasive strategy may alleviate the logistical and geographical barriers in timely reperfusion of ST-segment elevation myocardial infarction (STEMI), especially in a developing country like India.

Aim

To assess the safety and efficacy of pharmacoinvasive strategy versus primary PCI in STEMI patients at 2 years.

Methods

Patients enrolled in STEPP-AMI, an observational, multicenter, prospective study of 200 patients presenting with STEMI, were followed up for 2 years. Group ‘A’ comprised of patients with pharmacoinvasive strategy (n = 45), and patients who underwent primary PCI (n = 155) formed group ‘B’. Primary endpoint was composite of death, cardiogenic shock, reinfarction, repeat revascularization of the culprit artery, or congestive heart failure at 30 days, with follow-up till 2 years.

Results

The primary endpoint occurred in 11.1% and 17.8% in group A and in 3.9% and 13.6% in group B, at 30 days and 2 years, respectively (p = 0.07, RR = 2.87; 95% CI: 0.92–8.97 at 30 days and p = 0.47, RR = 1.31; 95% CI: 0.62–2.76). There was no difference in bleeding risk between groups, 2.2% in group A and 0.6% in group B (‘p’ = 0.4). The infarct-related artery patency varied at angiogram; it was 82.2% in arm A and 22.6% in arm B (‘p’ < 0.001). In group A, failed fibrinolysis occurred in 12.1%.

Conclusion

A pharmacoinvasive strategy resulted in outcomes that were comparable with primary PCI at 2 years, suggesting it might be a viable option in India. Larger studies are required to confirm these findings.