T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX
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- 作者：Kevin D. Cook1 ; 7 ; Karl B. Shpargel1 ; 2 ; 3 ; 7 ; Joshua Starmer1 ; 2 ; 3 ; Fatima Whitfield-Larry4 ; 5 ; Bridget Conley4 ; Denise E. Allard5 ; Julia E. Rager6 ; Rebecca C. Fry6 ; Marsha L. Davenport4 ; Terry Magnuson1 ; 2 ; 3 ; Jason K. Whitmire1 ; 5 ; 8 ; jwhitmir@email.unc.edu" class="auth_mail" title="E-mail the corresponding author ; Maureen A. Su3 ; 4 ; 5 ; 8 ; masu@email.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：43
- 期：4
- 页码：703-714
- 全文大小：2975 K
文摘
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T cell expression of UTX is required to clear a chronic virus infection
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UTX supports Tfh cell differentiation and subsequent B cell & antibody responses
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UTX-mediated H3K27me3 demethylation enforces Tfh gene-expression profile
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UTX expression and CD4+ CXCR5+ T cell frequency are reduced in Turner Syndrome