Sub-chronic (13-week) oral toxicity study, preceded by an in utero exposure phase and genotoxicity studies with fish source phosphatidylserine in rats
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- 作者：Y. Lifshitz ; yaell@enzymotec.com" class="auth_mail" title="E-mail the corresponding author ; L. Levi ; I. Eyal ; T. Cohen ; S. Tessler
- 关键词：InCog ; Phosphatidylserine ; DHA ; Infant ; 90-Day sub-chronic toxicity study ; Safety
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：86
- 期：Complete
- 页码：234-244
- 全文大小：545 K
文摘
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InCog™ (fish Phosphatidylserine-DHA) safety was examined for use in infants adults.
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In vitro genotoxicity studies show that InCog is not mutagenic.
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A sub-chronic study with an in-utero exposure phase was conducted.
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InCog has no effect on female fertility or embryonic development.
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The NOAEL is placed at mid dose diet, 2.1 g InCog/kg bw/day, 100 fold higher than infant's intake use.