Hydroxylation of methylated DNA by TET1 in chondrocyte differentiation of C3H10T1/2 cells
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- 作者：Ryo Itoa ; Hiroki Shimadaa ; Kengo Yazawaa ; Ikuko Satoa ; Yuuki Imaib ; Akira Sugawaraa ; Atsushi Yokoyamaa ; ayokoyama@med.tohoku.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：5mC ; 5-methylcytosine ; 5hmC ; 5-hydroxymethylcytosine ; Tet ; ten&ndash ; eleven translocation ; Col2 ; collagen 2 ; Col10 ; collagen 10 ; Igf1 ; insulin-like growth factor
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：134-140
- 全文大小：558 K
文摘
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The level of 5hmc increases concomitant with chondrocyte differentiation.
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Among the TET family proteins, the expression of TET1 is specifically facilitated in chondrocyte differentiation.
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Knock-down of TET1 leads to decrease in the expression of chondrocyte differentiation marker.
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TET proteins have a site preference for hydroxylation of 5mC on the Igf1 promoter.