The level of 5hmc increases concomitant with chondrocyte differentiation.
Among the TET family proteins, the expression of TET1 is specifically facilitated in chondrocyte differentiation.
Knock-down of TET1 leads to decrease in the expression of chondrocyte differentiation marker.
TET proteins have a site preference for hydroxylation of 5mC on the Igf1 promoter.