The metabolite 3,4,3ʹ,4ʹ-tetrachloroazobenzene (TCAB) exerts a higher ecotoxicity than the parent compounds 3,4-dichloroaniline (3,4-DCA) and propanil
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- 作者：Hongxia Xiaoa ; xiao.hongxia@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Jochen Kuckelkorna ; jochen.kuckelkorn@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Leonie Katharina Nü ; ß ; era ; leonie.nuesser@rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Tilman Floehra ; floehr@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Michael Patrick Henniga ; michael.hennig@rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Martina Roß ; -Nickolla ; c ; ross@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Andreas Schä ; ffera ; b ; c ; andreas.schaeffer@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author ; Henner Hollerta ; b ; c ; d ; henner.hollert@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Propanil ; 3 ; 4 ; 3ʹ ; 4ʹ-Tetrachloroazobenzene (TCAB) ; AhR-mediated activity ; Endocrine disrupting ; Zebrafish ; Quantitative structure activity response model (QSAR)
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：551-552
- 期：Complete
- 页码：304-316
- 全文大小：1390 K
文摘
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A relatively high TEF for AhR, low EEF and DEF of TCA were determined in vitro.
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Typical effects of AhR-agonists in zebrafish embryos were observed in vivo.
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QSAR predicted the binding affinity of TCAB to 16 human receptor in silico.
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TCAB might result in an adverse outcome in aquatic systems on the long term.