Polyphenols-rich Cyamopsis tetragonoloba (L.) Taub. beans show hypoglycemic and 尾-cells protective effects in type 2 diabetic rats
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- 作者：Gopalsamy Rajiv Gandhi ; Pautu Vanlalhruaia ; Antony Stalin ; Santiagu Stephen Irudayaraj ; Savarimuthu Ignacimuthu ; entolc@hotmail.com" class="auth_mail ; Michael Gabriel Paulraj
- 关键词：b wt. ; body weight ; FBG ; fasting blood glucose ; HFD ; high-fat diet ; ITT ; insulin tolerance test ; OGTT ; oral glucose tolerance test ; T2DM ; type 2 diabetes mellitus ; TC ; total cholesterol ; TG ; triglycerides ; STZ ; streptozotocin
- 刊名：Food and Chemical Toxicology
- 出版年：April, 2014
- 年：2014
- 卷：66
- 期：Complete
- 页码：358-365
- 全文大小：1639 K
文摘
The aim of this study was to evaluate the antidiabetic activity of Cyamopsis tetragonoloba (L.) Taub. (Fabaceae) beans in high-fat diet (HFD) fed-streptozotocin (STZ)-induced type 2 diabetic rats. Dose dependent response of oral treatment of C. tetragonoloba beans鈥?methanol extract (CTme) (200 and 400 mg/kg b wt.) was assessed by measuring fasting blood glucose, changes in body weight, plasma insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides, oral glucose tolerance, intraperitoneal insulin tolerance, hepatic glycogen, marker enzymes of carbohydrate metabolism in HFD fed-STZ-induced type 2 diabetic rats. Histology and immunohistochemical analysis of pancreatic islets were also performed. High-performance liquid chromatography (HPLC) analysis of CTme showed the presence of polyphenols such as gallic acid and caffeic acid in the concentrations of 2.46% (W/W) and 0.32% (W/W). CTme significantly reverted the altered biochemical parameters to near normal levels in diabetic rats. Furthermore CTme showed the protective effect on the 尾-cells of pancreatic tissues in diabetic rats. These findings indicate that C. tetragonoloba beans have therapeutic potential in HFD fed-STZ-induced hyperglycemia; therefore this can be used in the management of type 2 diabetes.