Versatile coordination modes of ronidazole towards transition metal ions: five and seven membered chelate rings; supramolecular networks

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• 作者：Paula Garcí ; a-Holley^a ; Naytzé ; Ortiz-Pastrana^a ; Rubé ; n A. Toscano^b ; Marcos Flores-Á ; lamo^a ; Norah Barba-Behrens^a ; ^{norah@unam.mx" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ronidazole ; Transition metal compounds ; Five and seven membered chelate rings ; Oxygen lone pair⋯π interactions ; Supramolecular arrangements
• 刊名：Polyhedron
• 出版年：2016
• 出版时间：28 January 2016
• 年：2016
• 卷：104
• 期：Complete
• 页码：127-137
• 全文大小：2563 K

文摘

Coordination compounds with ronidazole (ron) and the transition metals Co^II, Ni^II, Cu^II, Zn^II, Cd^II and Hg^II were synthesized and characterized by spectroscopic and analytical techniques. Ronidazole presented monodentate or bidentate coordination modes. A five membered chelate ring was formed by coordination of the carbamate oxygen (C–O–C) and the imidazole nitrogen atoms to the metal center. This coordination mode was observed in the halide compounds of cobalt(II) 1, 2, 3; copper(II) 8; zinc(II) 11, 12, 13; cadmium(II) 14, and mercury(II) 15. On the other hand, the ligand in the nitrate compounds of cobalt(II) 4, nickel(II) 7 and copper(II) 10, as the halide compounds of nickel(II) 5, 6 and copper(II) 9, formed a seven membered chelate ring through the carbonylic oxygen (CO) and the imidazolic nitrogen atoms to the metal ion. The coordination compounds presented tetrahedral, trigonal bipyramidal, and octahedral geometries. The X-ray crystal structures of ron and its coordination compounds presented intermolecular hydrogen bonding, oxygen lone pair⋯π and X⋯π interactions, giving place to complex 3D supramolecular structures.