Molecular mechanism of an anticancer triterpenoid AECHL-1 is revealed.
Upregulated ER stress by AECHL-1 is implicated in killing of breast cancer cells.
Anticancer activity of AECHL-1 is driven via mitochondrial calcium accumulation.
MCF-7 cells succumb to mitochondrial dysfunction and AIF mediated apoptosis.
AECHL-1 targets MDA-MB-231cells by activation of extrinsic apoptotic pathway.