Selective mechanism of action of dietary peptides from common bean on HCT116 human colorectal cancer cells through loss of mitochondrial membrane potential and DNA damage
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- 作者：Diego A. Luna-Vitala ; b ; Elvira Gonzá ; lez de Mejí ; ab ; edemejia@illinois.edu" class="auth_mail" title="E-mail the corresponding author ; Guadalupe Loarca-Piñ ; aa
- 关键词：NDF ; non-digestible fraction ; Δψm ; mitochondrial membrane potential ; ROS ; reactive oxygen species ; DIOC(6) ; 3 ; 3&prime ; -dihexyloxacarbocyanine iodide ; DCFDA ; 2&prime ; 7&prime ; - dichlorofluorescein diacetate ; TMRM ; tetramethylrhodamine ; methyl ester ; γ ; interaction index ; CI ; combination index ; SO ; superoxide ; NO ; nitric oxide ; HO ; hydroxyl
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：23
- 期：Complete
- 页码：24-39
- 全文大小：3538 K
文摘
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Dietary peptides GLTSK and GEGSGA inhibited selectively human colon cancer cells.
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Peptides from common bean enhanced oxaliplatin effects on HCT116 cells.
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GLTSK caused loss in mitochondrial potential and GEGSGA DNA damage.
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GEGSGA activated p53, increased p21, and decreased p-Rb inducing cell cycle arrest.