Direct exposure to N-methyl-d-aspartate alters mitochondrial function
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- 作者：Amit S. Kordea ; William F. Maragosa ; b ; william.maragos@va.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：A1/2 ; half maximum absorbance ; Amin ; minimum absorbance ; CCCP ; carbonyl cyanide m-chlorophenyl hydrazone ; CsA ; cyclosporin A ; DCF ; dihydrodichlorofluorescein diacetate ; ΔΨm ; mitochondrial membrane potential ; MK-801 ; dizocilpine ; NMDA ; N-methyl-d-aspartate ; NMDAm ; N-methyl-d-aspartate-sensitive site ; ROS ; reactive oxygen species ; TMRE ; tetramethylrhodamine ethyl ester
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：3 June 2016
- 年：2016
- 卷：623
- 期：Complete
- 页码：47-51
- 全文大小：867 K
文摘
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A previous study reported the detection of an NMDA-sensitive binding site on nervous system mitochondria.
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NMDA augmented mitochondrial ROS formation without altering membrane potential.
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NMDA attenuated cytochrome c release and delayed Ca2+-induced mitochondrial swelling.
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Activation of the NMDA-sensitive binding site may stabilize mitochondrial function.