Interferon-stimulated gene (ISG) 60, as well as ISG56 and ISG54, positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells
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- 作者：Tadaatsu Imaizumia ; timaizum@hirosaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hidemi Yoshidaa ; Ryo Hayakaria ; Fei Xinga ; Lian Wanga ; Tomoh Matsumiyaa ; Kunikazu Tanjib ; Shogo Kawaguchic ; Manabu Murakamid ; Hiroshi Tanakae ; f
- 关键词：IFN ; interferon ; IFN ; IFN induced proteins with tetratricopeptide repeats ; ISG ; IFN-stimulated gene ; poly IC ; polyinosinic&ndash ; polycytidylic acid ; STAT1 ; signal transducers and activators of transcription ; TLR ; Toll-like receptor
- 刊名：Neuroscience Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：35-41
- 全文大小：1189 K
文摘
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Poly IC induced ISG60 in U373MG cells.
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TLR3, IFN-β, ISG56 and ISG54 are involved in this reaction.
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ISG60, ISG54 and ISG56 positively regulate the level of phosphorylated STAT1.
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A positive feedback loop is created by phosphorylated STAT1 and these ISGs.
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ISG60 regulates CXCL10 expression induced by poly IC.