The innate immune response to RSV: Advances in our understanding of critical viral and host factors

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• 作者：Yan Sun ; Carolina B. Ló ; pez ; ^{lopezca@upenn.edu}
• 关键词：ATF6 ; activated transcription factor 6 ; BAP31 ; B-cell receptor-associated protein 31 ; Bcl2 ; B-cell lymphoma 2 ; DR4/5 ; death receptor 4/5 ; DUOX2 ; dual oxidase 2 ; DVGs ; defective viral genomes ; IB ; inclusion body ; IFIT1 ; interferon-induced protein with tetratricopeptide repeats 1 ; iNOS ; inducible nitric oxide synthase ; IRE1 ; inositol-requiring enzyme 1 ; JAK-STAT ; Janus kinase/signal transducers and activators of transcription ; MDA5 ; melanoma differentiation-associated protein 5 ; MyD88 ; myeloid dif
• 刊名：Vaccine
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：35
• 期：3
• 页码：481-488
• 全文大小：1211 K
• 卷排序：35

文摘

Innate RSV control involves the coordinated action of various cellular processes. These processes include cell stress, death, and innate immune responses. RSV utilizes multiple mechanisms to evade the host responses. RSV DVGs are the primary triggers of innate immunity in mice and humans. New evidence suggests a critical role of DVGs in RSV pathogenesis.