Conditioned medium from LS 174T goblet cells treated with oxyresveratrol strengthens tight junctions in Caco-2 cells

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• 作者：Dahyun Hwang^a ; HyunA Jo^b ; Seonwook Hwang^a ; Jeong-Keun Kim^c ; In-Ho Kim^d ; Young-Hee Lim^a ; ^b ; ^e ; ^{yhlim@korea.ac.kr}
• 关键词：Oxyresveratrol ; TFF3 ; Tight junction ; Goblet cell ; TEER
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：280-286
• 全文大小：1240 K
• 卷排序：85

文摘

Oxyresveratrol (OXY) increased TFF3 expression in LS 174T goblet cells. Conditioned medium was prepared from goblet cells treated with OXY (GCO-CM). GCO-CM increased the expression levels of claudin-1, occludin, and ZO-1. GCO-CM significantly increased tight junction integrity and reduced permeability. OXY strengthened tight junctions by stimulating TFF3 production in goblet cells.