TGFβ1 induces stress fiber formation through upregulation of TRPC6 in vascular smooth muscle cells

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• 作者：Soonbum Park^a ; Sanghoon Lee^b ; Eun-Jung Park^a ; MinJi Kang^a ; Insuk So^a ; ^c ; Ju-Hong Jeon^a ; ^c ; ^{jhjeon2@snu.ac.kr} ; Jung Nyeo Chun^a ; ^c ; ^{jungnyu@snu.ac.kr}
• 关键词：TGFβ1 ; Fibrosis ; Vascular smooth muscle ; TRPC6 ; Stress fiber
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：129-134
• 全文大小：1007 K
• 卷排序：483

文摘

TGFβ1 specifically elevates the expression level of TRPC6. TGFβ1 upregulates TRPC6 mainly through Smad-dependent canonical pathway. TRPC6 plays a crucial role in TGFβ1-induced stress fiber formation and cell migration.