Substrate stiffness promotes latent TGF-β1 activation in hepatocellular carcinoma

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• 作者：Mingshu Pang^a ; Yao Teng^a ; Jianyong Huang^a ; ^b ; ^{hjypku@gmail.com} ; Yuan Yuan^c ; Feng Lin^a ; Chunyang Xiong^a ; ^d ; ^{cyxiong@pku.edu.cn}
• 关键词：Hepatocellular carcinoma ; Substrate stiffness ; Traction forces ; Transforming growth factor β1 ; β1 integrin
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：553-558
• 全文大小：1108 K
• 卷排序：483

文摘

TGF-β1 signaling pathway regulated by ECM stiffness was studied in hepatocellular carcinoma. Matrix stiffness promoted latent TGF-β1 activation via β1 integrin-FAK-Rho GTPase pathway. A mechanism of how hepatocirrhosis developed into liver cancer was presented.