Thiazolidin-4-ones from 4-(methylthio)benzaldehyde and 4-(methylsulfonyl)benzaldehyde: Synthesis, antiglioma activity and cytotoxicity
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- 作者：Daniel Schuch da Silvaa ; b ; Cesar Emiliano Hoffmann da Silvaa ; b ; Mayara Sandrielly Pereira Soaresa ; c ; Juliana Hofstatter Azambujaa ; c ; Taí ; se Rosa de Carvalhoa ; c ; Geó ; rgia Cristiane Zimmerd ; Clarissa Piccinin Frizzod ; Elizandra Braganhola ; c ; Roselia Maria Spanevelloa ; c ; Wilson Cunicoa ; b ; wjcunico@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thiazolidin-4-ones ; Glioblastoma multiform ; Astrocytes ; Anti-tumor activity ; Necrosis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：574-582
- 全文大小：1307 K
文摘
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Fourteen novel 1,3-thiazolidin-4-ones were efficient obtained.
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Antitumor C6 assay highlights two compounds with activity at 5 μM.
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Three of top four on anti-tumor test were not cytotoxic to normal cell at 250 μM.
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Thiazolidinones as potential anti-GBM effect with safe therapeutic profile.