Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives
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- 作者：Celeste De Montea ; Simone Carradorib ; simone.carradori@unich.it" class="auth_mail" title="E-mail the corresponding author ; Bruna Bizzarria ; Adriana Bolascoa ; Federica Capraraa ; Adriano Mollicab ; Daniela Rivanerac ; Emanuela Marid ; Alessandra Zicarid ; Atilla Akdemire ; Daniela Seccia
- 关键词：Antimycotic effect ; Candida spp. ; Cytotoxicity ; N-substituted thiazolidinones
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：82-96
- 全文大小：2492 K
文摘
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Design and synthesis of a large library of N-substituted-1,3-thiazolidin-4-ones.
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They could be used as new lead compounds for the design of broad anti-Candida agents.
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Aliphatic moieties at the hydrazonic portion improved the biological activity of the scaffold.
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Some compounds displayed low cytotoxicity (CC50) against Hep2 cells.
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30">Docking studies suggested an inhibitory activity against lanosterol 14-α demethylase.