Visual Acuity Is Correlated with the Area of the Foveal Avascular Zone in Diabetic Retinopathy and Retinal Vein Occlusion

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• 作者：Chandrakumar Balaratnasingam ; MD ; PhD¹ ; ² ; ³ ; ⁴ ; ^{balaratnasingam@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Maiko Inoue ; MD¹ ; ² ; Seungjun Ahn ; MS⁵ ; Jesse McCann ; MD ; PhD¹ ; ² ; ³ ; Elona Dhrami-Gavazi ; MD¹ ; ² ; ³ ; Lawrence A. Yannuzzi ; MD¹ ; ² ; K. Bailey Freund ; MD¹ ; ² ; ³
• 关键词：BRVO ; branch retinal vein occlusion ; CRVO ; central retinal vein occlusion ; CST ; central subfield thickness ; DR ; diabetic retinopathy ; DRIL ; disorganization of the retinal inner layers ; ETDRS ; Early Treatment Diabetic Retinopathy Study ; EZ ; ellipsoid zone ; FA ; fluorescein angiography ; FAZ ; foveal avascular zone ; GEE ; generalized estimating equations ; ILM ; inner limiting membrane ; LogMAR ; logarithm of the minimum angle of resolution ; OCT ; optical coherence tomography ; OCTA ; optical coherence tomog
• 刊名：Ophthalmology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：123
• 期：11
• 页码：2352-2367
• 全文大小：4781 K

文摘

To determine if the area of the foveal avascular zone (FAZ) is correlated with visual acuity (VA) in diabetic retinopathy (DR) and retinal vein occlusion (RVO).

Design

Cross-sectional study.

Participants

Ninety-five eyes of 66 subjects with DR (65 eyes), branch retinal vein occlusion (19 eyes), and central retinal vein occlusion (11 eyes).

Methods

Structural optical coherence tomography (OCT; Spectralis, Heidelberg Engineering) and OCT angiography (OCTA; Avanti, Optovue RTVue XR) data from a single visit were analyzed. FAZ area, point thickness of central fovea, central 1-mm subfield thickness, the occurrence of intraretinal cysts, ellipsoid zone disruption, and disorganization of retinal inner layers (DRIL) length were measured. VA was also recorded. Correlations between FAZ area and VA were explored using regression models. Main outcome measure was VA.

Results

Mean age was 62.9±13.2 years. There was no difference in demographic and OCT-derived anatomic measurements between branch retinal vein occlusion and central retinal vein occlusion groups (all P ≥ 0.058); therefore, data from the 2 groups were pooled together to a single RVO group for further statistical comparisons. Univariate and multiple regression analysis showed that the area of the FAZ was significantly correlated with VA in DR and RVO (all P ≤ 0.003). The relationship between FAZ area and VA varied with age (P = 0.026) such that for a constant FAZ area, an increase in patient age was associated with poorer vision (rise in logarithm of the minimum angle of resolution visual acuity). Disruption of the ellipsoid zone was significantly correlated with VA in univariate and multiple regression analysis (both P < 0.001). Occurrence of intraretinal cysts, DRIL length, and lens status were significantly correlated with VA in the univariate regression analysis (P ≤ 0.018) but not the multiple regression analysis (P ≥ 0.210). Remaining variables evaluated in this study were not predictive of VA (all P ≥ 0.225).

Conclusions

The area of the FAZ is significantly correlated with VA in DR and RVO and this relationship is modulated by patient age. Further study about FAZ area and VA correlations during the natural course of retinal vascular diseases and following treatment is warranted.