Let thy left brain know what thy right brain doeth: Inter-hemispheric compensation of functional deficits after brain damage

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• 作者：Paolo Bartolomeo^a ; ^b ; Michel Thiebaut de Schotten^a ; ^b ; ^c ; ^{michel.thiebaut@gmail.com}
• 关键词：Brain ; Hemisphere ; Stroke ; Recovery ; Asymmetry ; Neurogenesis ; White matter ; Connections ; Phenotypes ; Stratification ; Longitudinal
• 刊名：Neuropsychologia
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：93
• 期：part_PB
• 页码：407-412
• 全文大小：2891 K
• 卷排序：93

文摘

Recent evidence revealed the importance of inter-hemispheric communication for the compensation of functional deficits after brain damage. This review summarises the biological consequences observed using histology as well as the longitudinal findings measured with magnetic resonance imaging methods in brain damaged animals and patients. In particular, we discuss the impact of post-stroke brain hyperactivity on functional recovery in relation to time. The reviewed evidence also suggests that the proportion of the preserved functional network both in the lesioned and in the intact hemispheres, rather than the simple lesion location, determines the extent of functional recovery. Hence, future research exploring longitudinal changes in patients with brain damage may unveil potential biomarkers underlying functional recovery.