Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives

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• 作者：Bin Zhu ; Brett A. Marinelli ; Darren Abbanat ; Barbara D. Foleno ; Karen Bush ; Mark J. Macielag
• 关键词：Erythromycin A ; Macrolide ; Ketolide ; Antibacterial
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 出版时间：15 July 2007
• 年：2007
• 卷：17
• 期：14
• 页码：3900-3904
• 全文大小：167 K

文摘

A series of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.