Indolyl-3-ethanone-α-thioethers: A promising new class of non-toxic antimalarial agents
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- 作者：Archibald L. Svogiea ; Michelle Isaacsb ; Heinrich C. Hoppeb ; Setshaba D. Khanyec ; Clinton G.L. Vealea ; C.Veale@ru.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Indolyl-3-ethanone-α-thioethers ; Plasmodium falciparum ; Antimalarial ; Selective inhibition
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：114
- 期：Complete
- 页码：79-88
- 全文大小：1219 K
文摘
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We describe the discovery of indolyl-3-ethanone-α-thioethers as a new class of antimalarial agents.
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SAR investigations uncovered two low nanomolar inhibitors of whole cell Plasmodium falciparum.
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Majority of compounds explored exhibited no measurable toxicity to HeLa cells.