Synthesis of 尾-disubstituted 尾-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates

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• 作者：Jason Guernon ; Lawrence Marcin ; Mendi Higgins ; Fukang Yang ; Jianliang Shi ; Lawrence Snyder ; Lorin A. Thompson ; Yong-Jin Wu ; ^{yong-jin.wu@bms.com" class="auth_mail}
• 关键词：N-Sulfinyl 尾-amino isoxazolyl ketone ; tert-Butanesulfinyl ketimine ; 1-(3 ; 5-Dimethylisoxazol-4-yl)ethanone ; 尾-Aryl-尾-methyl aminoalcohol
• 刊名：Tetrahedron Letters
• 出版年：26 March, 2014
• 年：2014
• 卷：55
• 期：13
• 页码：2134-2137
• 全文大小：1332 K

文摘

A series of 尾-disubstituted N-sulfinyl 尾-amino isoxazolyl ketones has been prepared by addition of tert-butanesulfinyl ketimines with the n-BuLi-generated enolates of isoxazolyl methyl ketones.