Deficiency of respiratory chain complex I in Hashimoto thyroiditis
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- 作者：Franz A. Zimmermanna ; b ; f.zimmermann@salk.at" class="auth_mail" title="E-mail the corresponding author ; Daniel Neureiterc ; d.neureiter@salk.at" class="auth_mail" title="E-mail the corresponding author ; René ; G. Feichtingera ; b ; r.feichtinger@salk.at" class="auth_mail" title="E-mail the corresponding author ; Andrea Trostd ; a.zurl@salk.at" class="auth_mail" title="E-mail the corresponding author ; Wolfgang Sperla ; w.sperl@salk.at" class="auth_mail" title="E-mail the corresponding author ; Barbara Koflera ; b ; b.kofler@salk.at" class="auth_mail" title="E-mail the corresponding author ; Johannes A. Mayra ; h.mayr@salk.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：OC ; Oncocytic cell ; HT ; Hashimoto thyroiditis ; OXPHOS ; oxidative phosphorylation ; TPO ; thyroid peroxidase ; mtDNA ; mitochondrial DNA
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：26
- 期：Complete
- 页码：1-6
- 全文大小：1908 K
文摘
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Oncocytic cells in Hashimoto thyroiditis show a high degree of complex I deficiency.
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Complex I deficiency might increase resistance to cell death in oncocytic cells.
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Oncocytic cells might trigger chronic inflammation in Hashimoto thyroiditis.